Endothelin 1 (EDN1) Rabbit Polyclonal Antibody

CAT#: TA364232

Rabbit polyclonal anti Big Endothelin-1 (hu); purified rabbit IgG


USD 655.00

2 Weeks*

Size
    • 400 ug

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Specifications

Product Data
Applications ELISA
Recommended Dilution This antibody has been tested and validated in ELISA against Big Endothelin-1. Other applications like immunohistochemistry (IHC), FACS or Western Blot may work as well. Optimal dilutions should be determined by the end user.
Reactivities Human
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys- Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val- Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg-Ser-OH (Disulfide bridge: 1 - 15 and 3 - 11) coupled to carrier protein.
Formulation Protein A affinity purified from antiserum, lyophilized, packaged under nitrogen. Reconstitute by adding 0.2ml distilled water. This stock solution contains 2mg/ml IgG, phosphate buffer saline pH 7.4 (PBS), and 0.02% (w/v) Thimerosal as a preservative.
Concentration N/A
Conjugation Unconjugated
Storage Original vial: at least one year at 4° - 8°C from date of delivery. Minimize repeated thawing and freezing of the antiserum by freezing aliquots at -20°C or below.
Gene Name endothelin 1
Background Big Endothelin-1 (Big ET), is a 38-amino-acid peptide and biological precursor of the potent vasoconstrictor Endothelin-1. It is cleaved to yield endothelin-1 and the C-terminal fragment (22-38) via the activity of a membrane-bound metalloproteinase called endothelin-converting enzyme (ECE). Endothelin is produced by several cell types including vascular endothelial cells, Mesangial cells and kidney cells. Big Endothelin-1 can be hydrolyzed by chymase to generate endothelin 1 (1-21) in vitro. This antibody was generated by immunization of rabbits with Big Endothelin-1 coupled to a carrier protein.
Synonyms ET1; HDLCQ7; PPET1; Preproendothelin-1
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.