Adm Rabbit Polyclonal Antibody

CAT#: TA364336

Rabbit polyclonal anti Proadrenomedullin (45-92) (hu); purified rabbit IgG

Specifications

Product Data

• Applications: ELISA
• Recommended Dilution: This antibody has been tested and validated in ELISA against Proadrenomedullin (45-92). Other applications like immunohistochemistry (IHC), FACS or Western Blot may work as well. Optimal dilutions should be determined by the end user.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide H-Glu-Leu-Arg-Met-Ser-Ser-Ser-Tyr-Pro-Thr-Gly-Leu- Ala-Asp-Val-Lys-Ala-Gly-Pro-Ala-Gln-Thr-Leu-Ile-Arg-Pro-Gln-Asp-Met- Lys-Gly-Ala-Ser-Arg-Ser-Pro-Glu-Asp-Ser-Ser-Pro-Asp-Ala-Ala-Arg-Ile- Arg-Val-OH coupled to a carrier protein.
• Formulation: Protein A affinity purified from antiserum, lyophilized, packaged under nitrogen. Reconstitute by adding 0.2ml distilled water. This stock solution contains 2mg/ml IgG, phosphate buffer saline pH 7.4 (PBS), and 0.02% (w/v) Thimerosal as a preservative.
• Concentration: N/A
• Conjugation: Unconjugated
• Storage: Original vial: at least one year at 4° - 8°C from date of delivery. Minimize repeated thawing and freezing of the antiserum by freezing aliquots at -20°C or below.
• Gene Name: adrenomedullin
• Database Link:
  UniProt ID P43145
• Background: Proadrenomedullin (45-92) (MR-proADM) is a peptide that is comprised of amino acid residues 45-92 of preproadrenomedullin. It has no effect on precontracted isolated cat pulmonary arterial rings when used at concentrations up to 10 µM, unlike adrenomedullin (1- 52) and adrenotensin, which induce relaxation and contraction, respectively. Levels of Proadrenomedullin are elevated in the plasma of patients with sepsis and those with cardiovascular disease and positively correlate with disease severity in patients with community-acquired pneumonia. This antibody was generated by immunization of rabbits with Proadrenomedullin (45-92) coupled to a carrier protein.
• Synonyms: adrenomedullin; AM; preproadrenomedullin