prothymosin, alpha (PTMA) Rabbit Polyclonal Antibody

CAT#: TA364341

Rabbit polyclonal anti Thymosin a1; purified rabbit IgG

Specifications

Product Data

• Applications: ELISA
• Recommended Dilution: This antibody has been tested and validated in ELISA against Thymosin α-1. Other applications like immunohistochemistry (IHC), FACS or Western Blot may work as well. Optimal dilutions should be determined by the end user.
• Reactivities: Human, Mammalian
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide Ac-Ser-Asp-Ala-Ala-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr- Lys-Asp-Leu-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH coupled to a carrier protein.
• Formulation: Protein A affinity purified from antiserum, lyophilized, packaged under nitrogen. Reconstitute by adding 0.2ml distilled water. This stock solution contains 2mg/ml IgG, phosphate buffer saline pH 7.4 (PBS), and 0.02% (w/v) Thimerosal as a preservative.
• Concentration: N/A
• Conjugation: Unconjugated
• Storage: Original vial: at least one year at 4° - 8°C from date of delivery. Minimize repeated thawing and freezing of the antiserum by freezing aliquots at -20°C or below.
• Gene Name: prothymosin, alpha
• Database Link:
  Entrez Gene 5757 Human
  UniProt ID P06454
• Background: Thymosins are small proteins isolated from the thymus, but most are now known to be also present in many other tissues. Thymosins have diverse biological activities, and two in particular, thymosins α1 and β4, have potentially important uses in medicine. Thymosin α-1 is a 28-amino acids peptide fragment derived from prothymosin alpha, a protein that in humans is encoded by the PTMA gene and it is believed to be a major component of Thymosin Fraction 5 responsible for the activity of that preparation in restoring immune function in animals lacking thymus glands. Thymosin β-4 is a 43-amino acids protein that in humans is encoded by the TMSB4X gene. It is a major cellular constituent in many tissues. Its intracellular concentration may reach as high as 0.5 mM. Following Thymosin α1, β4 was the second of the biologically active peptides from Thymosin Fraction 5 to be completely sequenced and synthesized. This antibody was generated by immunization of rabbits with Thymosin α-1 coupled to a carrier protein.
• Synonyms: MGC104802; TMSA