APLP1 Rabbit Polyclonal Antibody

CAT#: TA364353

Rabbit polyclonal anti APLP1-derived Ab-like Peptide (1-28) (APL1b28); purified rabbit IgG

Specifications

Product Data

• Applications: ELISA
• Recommended Dilution: This antibody has been tested and validated in ELISA against APL1β28. Other applications like immunohistochemistry (IHC), FACS or Western Blot may work as well. Optimal dilutions should be determined by the end user.
• Reactivities: Human, Mammalian
• Host: Rabbit
• Clonality: Polyclonal
• Formulation: Protein A affinity purified from antiserum, lyophilized, packaged under nitrogen. Reconstitute by adding 0.2ml distilled water. This stock solution contains 2mg/ml IgG, phosphate buffer saline pH 7.4 (PBS), and 0.02% (w/v) Thimerosal as a preservative.
• Concentration: N/A
• Conjugation: Unconjugated
• Storage: Original vial: at least one year at 4° - 8°C from date of delivery. Minimize repeated thawing and freezing of the antiserum by freezing aliquots at -20°C or below.
• Gene Name: amyloid beta precursor like protein 1
• Database Link:
  Entrez Gene 333 Human
  UniProt ID P51693
• Background: APLP1 (amyloid precursor-like protein 1) is part of a conserved family of type-I transmembrane proteins, including the amyloid precursor protein (APP) and APLP2 (amyloid precursor-like protein 2) which are homologous in function. APP and APLPs have roles in neuronal differentiation, synaptogenesis, neurite outgrowth, and synaptic plasticity. Subsequent γ-cleavage of membrane-bound stubs of APLP1 generates Aβ-like peptides with 25, 27 and 28 residues. APL1β28 has been suggested to be a surrogate marker for Aβ1–42 production in the brain. This antibody was generated by immunization of rabbits with APL1β28 coupled to a carrier protein.
• Synonyms: APLP; APLP-1