ProDynorphin (PDYN) Guinea Pig Polyclonal Antibody

CAT#: TA364387

Guinea pig polyclonal anti Dynorphin B; diluted antiserum


USD 965.00

2 Weeks*

Size
    • 500 Tests

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Specifications

Product Data
Applications ELISA
Recommended Dilution This antibody has been tested and validated in ELISA against Dynorphin B. Other applications like immunohistochemistry (IHC), FACS or Western Blot may work as well. Optimal dilutions should be determined by the end user.
Reactivities Human, Mammalian
Host Guinea Pig
Clonality Polyclonal
Immunogen Synthetic peptide H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Gln-Phe-Lys-Val-Val- Thr-OH coupled to carrier protein.
Formulation This polyclonal antibody is supplied as a lyophilized powder. The powder should be rehydrated with 50ml RIA buffer. Upon reconstitution to 50ml total volume, the solution contains 0.1M sodium phosphate buffer (pH 7.4), 0.05M NaCl, 0.1% BSA, 0.01% NaN3, and 0.1% Triton X-100. Store at 4°C. This should ensure antibody stability for approximately one month.
Concentration N/A
Conjugation Unconjugated
Storage Original vial: at least one year at 4° - 8°C from date of delivery. Minimize repeated thawing and freezing of the antiserum by freezing aliquots at -20°C or below.
Gene Name prodynorphin
Background Dynorphins are a class of opioid peptides. As their precursor Proenkephalin-B is cleaved during processing, its residues 207-223 (Dynorphin A) and 226-238 (Rimorphin, Dynorphin B) are released, among others. Dynorphin A (1-13) is conserved among various species. Dynorphins contain a high proportion of basic and hydrophobic residues. They are widely distributed in the central nervous system, with highest concentrations in the hypothalamus, medulla, pons, midbrain, and spinal cord, where they are also produced. Dynorphins are stored in large dense-core vesicles characteristic of opioid peptides storage. Dynorphins exert their effects primarily through the κ-opioid receptor (KOR), a G-protein- coupled receptor. They are part of the complex molecular changes in the brain leading to cocaine addiction. Dynorphins are important in maintaining homeostasis through appetite control, circadian rhythms and the regulation of body temperature. However, Dynorphin derivatives are generally considered to be of little clinical use because of their very short duration of action. This antibody was generated by immunization of guinea pigs with Dynorphin B coupled to a carrier protein.
Synonyms beta-neoendorphin; beta-neoendorphin-dynorphin; dynorphin; leu-enkephalin; leumorphin; MGC26418; PENKB; preprodynorphin; prodynorphin; rimorphin
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.