CHRNA4 Rabbit Polyclonal Antibody

CAT#: TA364526

CHRNA4 rabbit polyclonal antibody

Product Images

Immunohistochemistry of paraffin-embedded Human brain tissue using TA364526 (CHRNA4 Antibody) at dilution 1/40 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human brain tissue using TA364526 (CHRNA4 Antibody) at dilution 1/40, treated with fusion protein. (Original magnification: ×200)

Specifications

Product Data

• Applications: ELISA, IHC
• Recommended Dilution: IHC: 50-200
  Positive control: Human brain
  Predicted cell location: Cytoplasm
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein of human CHRNA4
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C.
• Stability: 1 year
• Database Link:
  UniProt ID P43681
• Background: This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1.