BDH2 Rabbit Polyclonal Antibody

CAT#: TA365517

BDH2 rabbit polyclonal antibody

Product Images

Gel: 12%SDS-PAGE Lysate: 40 μg Lane 1-3:293T and A172 cell Mouse kidney tissue lysates Primary antibody: TA365517 (BDH2 Antibody) at dilution 1/300 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 15 seconds

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 500-2000
  WB positive control: 293T and A172 cell，Mouse kidney tissue lysates
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Full length fusion protein
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C.
• Stability: 1 year
• Predicted Protein Size: 27 kDa
• Database Link:
  UniProt ID Q9BUT1
• Background: DHRS6 (dehydrogenase/reductase SDR family member 6), also known as EFA6R, SDR15C1, UCPA-OR,UNQ6308 or BDH2, is a 245 amino acid cytoplasmic protein belonging to the short-chain dehydrogenases/reductases (SDR) family, an evolutionarily conserved family of oxidoreductases found in all forms of life. DHRS6 is a novel, cytosolic type II R-β-hydroxybutyrate dehydrogenase that exists as two alternatively spliced isoforms and may have an essential role as a nutrient or building block in cellular survival. Human DHRS6 and its vertebrate orthologs show high levels of sequence identities to bacterial hydroxybutyrate dehydrogenases. DHRS6 may play an important role in the peripheral utilization of 3-hydroxybutyrate and its cytoplasmic localization with its high ratio of oxidized NAD+, the NAD+ dependence and the kinetic parameters of DHRS6 make it suitable to convert high levels of circulating 3-hydroxybutyrate into acetoacetate.