LSM10 Rabbit Polyclonal Antibody

CAT#: TA365932

LSM10 rabbit polyclonal antibody

Product Images

Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using TA365932 (LSM10 Antibody) at dilution 1/100 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using TA365932 (LSM10 Antibody) at dilution 1/100, treated with fusion protein. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 50-300
  Positive control: Human thyroid cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein of human LSM10
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C.
• Stability: 1 year
• Database Link:
  UniProt ID Q969L4
• Background: LSm10 (U7 snRNA-associated Sm-like protein LSm10) is a nuclear protein that belongs to the snRNP (small nuclear ribonucleoproteins) Sm protein family. The survival of motor neurons (SMN) complex mediates the assembly of snRNPs involved in splicing and histone RNA processing. A crucial step in this process is the binding of Sm proteins onto the SMN protein. LSm10 and LSm11, mammalian homologs of the yeast Sm proteins D1 and D2, are important for U7 snRNP function and subcellular localization. U7 snRNP is an RNA molecule involved in the splicing of animal histone pre-mRNAs. Lsm10 and Lsm11 also associate with pICln (Chloride ion current inducer protein), which interacts with Sm proteins to inhibit their assembly on U RNA. LSm10 interactions with U7 snRNA and pICln may provide the means for using modified U7 snRNA derivatives to alter specific pre-mRNA splicing events, potentially leading to advances in antisense gene therapy.