ZNHIT3 Rabbit Polyclonal Antibody

CAT#: TA367768

ZNHIT3 rabbit polyclonal antibody


USD 380.00

4 Weeks*

Size
    • 100 ul

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Specifications

Product Data
Applications IHC
Recommended Dilution IHC: 45-300
Positive control: Human esophagus cancer
Predicted cell location: Nucleus
Reactivities Human
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Synthetic peptide of human ZNHIT3
Formulation pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Store at -20°C.
Stability 1 year
Background ZNHIT3 (zinc finger, HIT-type containing 3), also known as TRIP3 (thyroid receptor-interacting protein 3) or HNF-4a coactivator, is a 155 amino acid protein that contains one HIT-type zinc finger and regulates PPAR©-mediated adipocyte differentiation. ZNHIT3 also coactivates HNF-4å, and as a thyroid receptor interacting protein, ZNHIT3 interacts with the ligand binding domain of the thyroid receptor. The gene encoding ZNHIT3 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.