YTHDF1 Rabbit Polyclonal Antibody
Other products for "YTHDF1"
Specifications
Product Data | |
Applications | IHC |
Recommended Dilution | IHC: 40-200 Positive control: Human cervical cancer Predicted cell location: Cytoplasm |
Reactivities | Human, Mouse |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Synthetic peptide of human YTHDF1 |
Formulation | pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Concentration | lot specific |
Purification | Antigen affinity purification |
Conjugation | Unconjugated |
Storage | Store at -20°C. |
Stability | 1 year |
Database Link | |
Background | YTHDF1, also designated Dermatomyositis associated with cancer putative autoantigen 1 (DACA-1), is a 559 amino acid protein that contains one YTH domain, which is a potential RNA binding domain. Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and promotes mRNA translation efficiency (PubMed:24284625, PubMed:26046440, PubMed:26318451). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:24284625). Acts as a regulator of mRNA translation efficiency: promotes ribosome loading to m6A-containing mRNAs and interacts with translation initiation factors eIF3 (EIF3A or EIF3B) to facilitate translation initiation (PubMed:26046440). |
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