MARK1 Rabbit Polyclonal Antibody

CAT#: TA371417

MARK1 rabbit polyclonal antibody


USD 380.00

4 Weeks*

Size
    • 100 ul

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Specifications

Product Data
Applications IHC
Recommended Dilution IHC: 50-200
Positive control: Human brain
Predicted cell location: Cytoplasm and Nucleus
Reactivities Human
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Synthetic peptide of human MARK1
Formulation pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Store at -20°C.
Stability 1 year
Gene Name microtubule affinity regulating kinase 1
Background The microtubule matrix within a cell plays a central role in intracellular transport, cell shape during differentiation and chromosome partitioning during mitosis. During these processes, microtubules transition rapidly between stable and dynamic states. MAP/microtubule affinity-regulating kinase 1 (MARK1) is a 795 amino acid protein belonging to the CAMK Ser/Thr protein kinase family. MARK1 is thought to play a role in the stability of the microtubule matrix of the cytoskeleton. MARK1 is activated by phosphorylation of Thr215 by LKB1 in complex with STRAD and MO25. Localized to the cytoskeleton, MARK1 contains one kinase-associated (KA1) domain, one protein kinase domain and one UBA domain. Expressed as three isoforms produced by alternative splicing, MARK1 is found with highest levels in brain, skeletal muscle and heart.
Synonyms KIAA1477; MARK; MGC126512; MGC126513
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.