Estrogen Receptor 1 (ESR1) Rabbit Polyclonal Antibody

CAT#: TA372910

ESR1 rabbit polyclonal antibody


USD 380.00

4 Weeks*

Size
    • 100 ul

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Specifications

Product Data
Applications IHC, WB
Recommended Dilution WB: 500-2000
WB positive control: NIH/3T3 and HepG2 cell lysates
IHC: 50-100
Positive control: Human esophagus cancer
Predicted cell location: Nucleus
Reactivities Human, Mouse
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Synthetic peptide of human ESR1
Formulation pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Store at -20°C.
Stability 1 year
Predicted Protein Size 66 kDa
Gene Name estrogen receptor 1
Background This gene encodes an estrogen receptor and ligand-activated transcription factor. The canonical protein contains an N-terminal ligand-independent transactivation domain, a central DNA binding domain, a hinge domain, and a C-terminal ligand-dependent transactivation domain. The protein localizes to the nucleus where it may form either a homodimer or a heterodimer with estrogen receptor 2. The protein encoded by this gene regulates the transcription of many estrogen-inducible genes that play a role in growth, metabolism, sexual development, gestation, and other reproductive functions and is expressed in many non-reproductive tissues. The receptor encoded by this gene plays a key role in breast cancer, endometrial cancer, and osteoporosis. This gene is reported to have dozens of transcript variants due to the use of alternate promoters and alternative splicing, however, the full-length nature of many of these variants remain uncertain.
Synonyms DKFZp686N23123; ER; ER-alpha; Era; ESR; ESRA; NR3A1
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.