ATR Rabbit Polyclonal Antibody

CAT#: TA373042

ATR rabbit polyclonal antibody

Product Images

Gel: 6%SDS-PAGE Lysate: 40 μg Lane: A549 cell lysate Primary antibody: TA373042 (ATR Antibody) at dilution 1/650 Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution Exposure time: 2 minutes

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 200-1000
  WB positive control: A549 cell lysate
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human ATR
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C.
• Stability: 1 year
• Predicted Protein Size: 301 kDa
• Gene Name: ATR serine/threonine kinase
• Database Link:
  Entrez Gene 545 Human
  UniProt ID Q13535
• Background: The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.
• Synonyms: FRP1; MEC1; SCKL; SCKL1