DCC Rabbit Polyclonal Antibody

CAT#: TA375344

DCC Rabbit polyclonal Antibody


USD 220.00

3 Weeks*

Size
    • 100 ul

Product Images

Specifications

Product Data
Applications WB
Recommended Dilution WB,1:500 - 1:1000
Reactivities Human, Mouse
Modifications Unmodified
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen A synthetic peptide of human DCC
Formulation Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Concentration lot specific
Purification Affinity purification
Conjugation Unconjugated
Stability Shelf life: one year from despatch.
Predicted Protein Size 158kDa
Gene Name DCC netrin 1 receptor
Background This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.