DCPS Rabbit Polyclonal Antibody

CAT#: TA375355

DCPS Rabbit polyclonal Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB,1:1000 - 1:2000
• Reactivities: Human
• Modifications: Unmodified
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human DCPS (NP_054745.1).
• Formulation: Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: 38kDa
• Gene Name: decapping enzyme, scavenger
• Database Link:
  Entrez Gene 28960 Human
  UniProt ID Q96C86
• Background: Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG with up to 10 nucleotide substrates (small capped oligoribonucleotides and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP. Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7GpppG with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP to m7GMP. May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCPS to m7GMP. Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death.