elF2 alpha (EIF2S1) Rabbit Polyclonal Antibody
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Other products for "EIF2S1"
Specifications
Product Data | |
Applications | IHC, IP, WB |
Recommended Dilution | WB,1:1000 - 1:2000 IHC,1:50 - 1:200 IP,1:50 - 1:100 |
Reactivities | Human, Mouse, Rat |
Modifications | Phospho S51 |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | A synthetic phosphorylated peptide around S51 of human eIF2α (NP_004085.1). |
Formulation | Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
Concentration | lot specific |
Purification | Affinity purification |
Conjugation | Unconjugated |
Stability | Shelf life: one year from despatch. |
Predicted Protein Size | 36kDa |
Gene Name | eukaryotic translation initiation factor 2 subunit alpha |
Database Link | |
Background | The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010] |
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