IGF1 Receptor (IGF1R) Rabbit Polyclonal Antibody

CAT#: TA377374

Phospho-INSR-Y1189/Y1190 + IGF1R-Y1165/Y1166 Rabbit polyclonal Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB,1:500 - 1:2000
• Reactivities: Human, Mouse, Rat
• Modifications: Phospho Y1189/Y1190,Phospho Y1165/Y1166
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A phospho specific peptide corresponding to residues surrounding Y1189/Y1190 of human INSR and Y1165/Y1166 of human IGF1R.
• Formulation: Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: 154kDa/155kDa/156kDa
• Gene Name: insulin like growth factor 1 receptor
• Database Link:
  Entrez Gene 3480 Human
  UniProt ID P08069
• Background: This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]