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EFHA1 (MICU2) Rabbit Polyclonal Antibody
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Other products for "MICU2"
Specifications
| Product Data | |
| Applications | WB |
| Recommended Dilution | WB,1:500 - 1:2000 |
| Reactivities | Human, Mouse, Rat |
| Modifications | Unmodified |
| Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 50-150 of human MICU2 (NP_689939.1). |
| Formulation | Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
| Concentration | lot specific |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Stability | Shelf life: one year from despatch. |
| Predicted Protein Size | 49kDa |
| Gene Name | mitochondrial calcium uptake 2 |
| Database Link | |
| Background | Key regulator of mitochondrial calcium uniporter (MCU required to limit calcium uptake by MCU when cytoplasmic calcium is low. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium. MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting calcium, avoiding energy dissipation and cell-death triggering. |
| Reference Data | |
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complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.