PDK1 Rabbit Polyclonal Antibody

CAT#: TA379764

PDK1/PDHK1 Rabbit polyclonal Antibody

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB,1:500 - 1:1000
  IF,1:50 - 1:200
• Reactivities: Human, Mouse, Rat
• Modifications: Unmodified
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human PDK1/PDHK1 (NP_002601.1).
• Formulation: Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: 49kDa/51kDa
• Gene Name: pyruvate dehydrogenase kinase 1
• Database Link:
  Entrez Gene 5163 Human
  UniProt ID Q15118
• Background: Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene.