RIC8 (RIC8A) Rabbit Polyclonal Antibody

CAT#: TA380926

RIC8A Rabbit polyclonal Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB,1:500 - 1:2000
• Reactivities: Human, Mouse, Rat
• Modifications: Unmodified
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 362-531 of human RIC8A (NP_001273063.1).
• Formulation: Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: 58kDa/59kDa/60kDa
• Gene Name: RIC8 guanine nucleotide exchange factor A
• Database Link:
  Entrez Gene 60626 Human
  UniProt ID Q9NPQ8
• Background: Guanine nucleotide exchange factor (GEF, which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i-alpha protein, possibly leading to release G(i-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i-alpha-GDP complex (By similarity. Also acts as an activator for G(q-alpha (GNAQ protein by enhancing the G(q-coupled receptor-mediated ERK activation.