p53 (TP53) Rabbit Polyclonal Antibody

CAT#: TA382723

Phospho-p53-S33 Rabbit polyclonal Antibody


USD 300.00

3 Weeks*

Size
    • 100 ul

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Specifications

Product Data
Applications IHC, IP, WB
Recommended Dilution WB,1:500 - 1:2000
IHC,1:50 - 1:100
IP,1:50 - 1:100
Reactivities Human, Mouse, Rat
Modifications Phospho S33
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen A synthetic phosphorylated peptide around S33 of human p53 (NP_000537.3).
Formulation Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Concentration lot specific
Purification Affinity purification
Conjugation Unconjugated
Stability Shelf life: one year from despatch.
Predicted Protein Size 23-43kDa
Gene Name tumor protein p53
Background This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.