ABCG2 Rabbit Polyclonal Antibody

CAT#: TA383648

ABCG2 Rabbit polyclonal Antibody

Product Images

Western Blot analysis of various cells using primary antibody diluted at 1:1000(4°C overnight). Secondary antibody：Goat Anti-rabbit IgG IRDye 800( diluted at 1:5000, 25°C, 1 hour)

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  Western Blot analysis of various cells using ABCG2 Polyclonal Antibody

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  Western Blot analysis of HT29 cells using ABCG2 Polyclonal Antibody

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  Immunohistochemistry analysis of paraffin-embedded human brain, using ABCG2 Antibody. The picture on the right is blocked with the ABCG2 peptide.

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  Western blot analysis of lysate from HT-29 cells, using ABCG2 antibody .

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Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: WB: 1/500-1/2000
  IHC: 1/100-1/300
  ELISA: 1/10000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The antiserum was produced against synthesized peptide derived from human ABCG2. AA range:289-338
• Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
• Concentration: lot specific
• Purification: Affinity Chromatography
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Observed MW (kDa):72
• Gene Name: ATP binding cassette subfamily G member 2 (Junior blood group)
• Database Link:
  Entrez Gene 9429 Human
  UniProt ID Q9UNQ0
• Background: Swiss-Prot Acc.Q9UNQ0.High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.
• Synonyms: ABC15; ABCP; BCRP; BCRP1; BMDP; CD338; CDw338; EST157481; MGC102821; MRX; MXR; MXR1