Angiopoietin like 4 (ANGPTL4) Rabbit Monoclonal Antibody [Clone ID: R04-1B5]

CAT#: TA383721

Angiopoietin Like 4 Rabbit monoclonal Antibody

Product Images

Western blot detection of Angiopoietin-like 4 in K562,Hela cell lysates using Angiopoietin-like 4 Rabbit mAb(1:1000 diluted).Predicted band size:45kDa.Observed band size:55kDa.

Specifications

Product Data

• Clone Name: R04-1B5
• Applications: WB
• Recommended Dilution: WB: 1/1000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Recombinant protein of human Angiopoietin-like 4
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 45 kDa; Observed MW: 55 kDa
• Gene Name: angiopoietin like 4
• Database Link:
  Entrez Gene 51129 Human
  UniProt ID Q9BY76
• Background: Swiss-Prot Acc.Q9BY76.Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation .
• Synonyms: ANGPTL2; ARP4; FIAF; HFARP; NL2; PGAR; pp1158