APE1 (APEX1) Rabbit Polyclonal Antibody

CAT#: TA383735

APE1 Rabbit polyclonal Antibody

Product Images

Western blot analysis of APE1 expression in K562 cell lysate.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1/1000-1/5000
  IHC: 1/50-1/200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthesized peptide derived from human APE1
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: lot specific
• Purification: Affinity Chromatography
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: 36kDa
• Gene Name: apurinic/apyrimidinic endodeoxyribonuclease 1
• Database Link:
  Entrez Gene 328 Human
  UniProt ID P27695
• Background: Swiss-Prot Acc.P27695.Ape1 initiates the repair of abasic sites and is essential for the base excision repair (BER) pathway. Repair activities of Ape1 are stimulated by interaction with XRCC1, another essential protein in BER. Ape1 functions as a redox factor that maintains transcription factors in an active, reduced state but can also function in a redox-independent manner as a transcriptional cofactor to control different cellular fates such as apoptosis, proliferation and differentiation.
• Synonyms: APE; APE-1; APE1; APEN; APEX; APX; HAP1; REF-1; REF1