ATF2 Rabbit Monoclonal Antibody [Clone ID: R07-3E5]

CAT#: TA383758

Phospho-ATF2 (Thr71) Rabbit monoclonal Antibody


USD 380.00

4 Weeks*

Size
    • 100 ul

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Specifications

Product Data
Clone Name R07-3E5
Applications IF, IP, WB
Recommended Dilution WB: 1/1000
ICC/IF: 1/100
IP: 1/20
Reactivities Human, Mouse
Host Rabbit
Isotype IgG
Clonality Monoclonal
Immunogen A synthetic phosphopeptide corresponding to residues surrounding Thr71 of human ATF2 (Phosphorylated)
Formulation 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration lot specific
Purification Affinity Purified
Conjugation Unconjugated
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Stability 1 year
Predicted Protein Size Calculated MW: 55 kDa; Observed MW: 70 kDa
Gene Name activating transcription factor 2
Background Swiss-Prot Acc.P15336.Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.
Synonyms CRE-BP1; CREB-2; CREB2; CREBP1; HB16; MGC111558; TREB7
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.