CTIP2 (BCL11B) Rabbit Monoclonal Antibody [Clone ID: R08-5K7]

CAT#: TA383809

Ctip2 Rabbit monoclonal Antibody

Specifications

Product Data

• Clone Name: R08-5K7
• Applications: WB
• Recommended Dilution: WB: 1/2000-1/10000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide of human Ctip2
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 96 kDa; Observed MW: 120-130 kDa
• Gene Name: B-cell CLL/lymphoma 11B
• Database Link:
  Entrez Gene 64919 Human
  UniProt ID Q9C0K0
• Background: Swiss-Prot Acc.Q9C0K0.Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4+ T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element . May also function in the P53-signaling pathway .
• Synonyms: CTIP-2; CTIP2; hRit1; hRIT1-alpha; RIT1