BCL2 Rabbit Monoclonal Antibody [Clone ID: R07-2A1]
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Specifications
Product Data | |
Clone Name | R07-2A1 |
Applications | IHC, WB |
Recommended Dilution | WB: 1/1000 IHC: 1/20-1/500 |
Reactivities | Human, Mouse |
Host | Rabbit |
Isotype | IgG |
Clonality | Monoclonal |
Immunogen | Recombinant protein of human Bcl-2 |
Formulation | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
Concentration | lot specific |
Purification | Affinity Purified |
Conjugation | Unconjugated |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Stability | 1 year |
Predicted Protein Size | Calculated MW: 26 kDa; Observed MW: 26 kDa |
Gene Name | B-cell CLL/lymphoma 2 |
Database Link | |
Background | Swiss-Prot Acc.P10415.Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785). |
Synonyms | Bcl-2; OTTHUMP00000163680 |
Reference Data |
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