Bcl x (BCL2L1) Rabbit Monoclonal Antibody [Clone ID: R02-2D3]

CAT#: TA383814

Bcl-XL Rabbit monoclonal Antibody

Specifications

Product Data

• Clone Name: R02-2D3
• Applications: IF, IHC, IP, WB
• Recommended Dilution: WB: 1/1000
  IHC: 1/200
  ICC/IF: 1/200
  IP: 1/20
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Recombinant protein of human Bcl-XL
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 26 kDa; Observed MW: 30 kDa
• Gene Name: BCL2 like 1
• Database Link:
  Entrez Gene 598 Human
  UniProt ID Q07817
• Background: Swiss-Prot Acc.Q07817.Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F1F0 activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).
• Synonyms: Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; Bcl2-L-1; BCL2L; BCLX; DKFZp781P2092; OTTHUMP00000030550