BIN1 Rabbit Monoclonal Antibody [Clone ID: R07-2C1]

CAT#: TA383819

BIN1 Rabbit monoclonal Antibody

Specifications

Product Data

• Clone Name: R07-2C1
• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1/1000
  IHC: 1/20
  ICC/IF: 1/20
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Recombinant protein of human BIN1
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 65 kDa; Observed MW: 45-80 kDa
• Gene Name: bridging integrator 1
• Database Link:
  Entrez Gene 274 Human
  UniProt ID O00499
• Background: Swiss-Prot Acc.O00499.Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed:24755653). Is a negative regulator of endocytosis . Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed:27179792). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates . May be involved in the regulation of MYC activity and the control cell proliferation (PubMed:8782822). Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro (PubMed:28893863).
• Synonyms: AMPH2; amphiphysin-like; AMPHL; DKFZp547F068; MGC10367; OTTHUMP00000203785; SH3P9