BNIP3 Rabbit Monoclonal Antibody [Clone ID: R09-1G8]

CAT#: TA383823

BNIP3 Rabbit monoclonal Antibody

Specifications

Product Data

• Clone Name: R09-1G8
• Applications: IF, WB
• Recommended Dilution: WB: 1/1000
  ICC/IF: 1/50
• Reactivities: Human, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide of human BNIP3
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 28 kDa; Observed MW: 28 kDa
• Gene Name: BCL2/adenovirus E1B 19kDa interacting protein 3
• Database Link:
  Entrez Gene 664 Human
  UniProt ID Q12983
• Background: Swiss-Prot Acc.Q12983.Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.
• Synonyms: NIP3