BubR1 (BUB1B) Rabbit Polyclonal Antibody
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Specifications
Product Data | |
Applications | FC, IHC, IP, WB |
Recommended Dilution | WB: 1/1000-1/5000 IHC: 1/50-1/200 IP: 1/30 FC: 1/50 |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | A synthesized peptide derived from human BubR1 |
Formulation | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Concentration | lot specific |
Purification | Affinity Chromatography |
Conjugation | Unconjugated |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Stability | 1 year |
Predicted Protein Size | 120kDa |
Gene Name | BUB1 mitotic checkpoint serine/threonine kinase B |
Database Link | |
Background | Swiss-Prot Acc.O60566.Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. |
Synonyms | Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; SSK1 |
Reference Data |
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