CAMK2A Rabbit Monoclonal Antibody [Clone ID: R05-9G5]

CAT#: TA383860

CaMKII beta Rabbit monoclonal Antibody

Product Images

Western blot detection of CaMKII in Mouse brain lysates using CaMKII Rabbit mAb(1:1000 diluted).Predicted band size:54KDa.Observed band size:54KDa.

Specifications

Product Data

• Clone Name: R05-9G5
• Applications: WB
• Recommended Dilution: WB: 1/1000
• Reactivities: Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide of human CaMKII
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 54 kDa; Observed MW: 54 kDa
• Gene Name: calcium/calmodulin dependent protein kinase II alpha
• Database Link:
  UniProt ID Q13554
• Background: Swiss-Prot Acc.Q13554.Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca2+ transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca2+ transport and in fast-twitch muscle participates in the control of Ca2+ release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.
• Synonyms: CAMKA; CaMKIINalpha; KIAA0968