Caveolin 1 (CAV1) Rabbit Monoclonal Antibody [Clone ID: R01-9C9]

CAT#: TA383887

Caveolin 1 Rabbit monoclonal Antibody

Product Images

Western blot detection of Caveolin-1 in Hela cell lysates using Caveolin-1 Rabbit mAb(1:1000 diluted).Predicted band size:20kDa.Observed band size:20kDa.

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  Immunohistochemistry analysis of paraffin-embedded Human breast cancer using Caveolin1 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Specifications

Product Data

• Clone Name: R01-9C9
• Applications: IHC, WB
• Recommended Dilution: WB: 1/1000-1/5000
  IHC: 1/20
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide of human Caveolin-1
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 20 kDa; Observed MW: 20 kDa
• Gene Name: caveolin 1
• Database Link:
  Entrez Gene 857 Human
  UniProt ID Q03135
• Background: Swiss-Prot Acc.Q03135.May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity . Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564).
• Synonyms: BSCL3; CAV; CGL3; MSTP085; VIP21