HP1 gamma (CBX3) Rabbit Monoclonal Antibody [Clone ID: R02-8A2]

CAT#: TA383894

HP1 gamma Rabbit monoclonal Antibody


USD 380.00

4 Weeks*

Size
    • 100 ul

Product Images

Other products for "CBX3"

Specifications

Product Data
Clone Name R02-8A2
Applications IHC, IP, WB
Recommended Dilution WB: 1/1000
IHC: 1/20-1/500
IP: 1/20
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Monoclonal
Immunogen A synthetic peptide of mouse HP1 gamma
Formulation 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration lot specific
Purification Affinity Purified
Conjugation Unconjugated
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Stability 1 year
Predicted Protein Size Calculated MW: 21 kDa; Observed MW: 21 kDa
Gene Name chromobox 3
Background Swiss-Prot Acc.P23198.Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Probably involved in the repression of many genes located in euchromatin, such as E2F1, MYC and CDC25A. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1 (PubMed:24413057). Mediates the recruitement of NIPBL to sites of DNA damage at double-strand breaks (DSBs) .
Synonyms HECH; HP1-GAMMA; HP1Hs-gamma
Reference Data

{0} Product Review(s)

0 Product Review(s) Submit review

Be the first one to submit a review

Product Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.