DGCR8 Rabbit Polyclonal Antibody

CAT#: TA384098

DGCR8 Rabbit polyclonal Antibody

Product Images

Western blot analysis of DGCR8 expression in (1) HEK293 cell lysate; (2) HeLa cell lysate.

Specifications

Product Data

• Applications: IF, IP, WB
• Recommended Dilution: WB: 1/500-1/2000
  ICC/IF: 1/100-1/500
  IP: 1/50
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthesized peptide derived from human DGCR8
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: lot specific
• Purification: Affinity Chromatography
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: 100kDa
• Gene Name: DGCR8 microprocessor complex subunit
• Database Link:
  Entrez Gene 54487 Human
  UniProt ID Q8WYQ5
• Background: Swiss-Prot Acc.Q8WYQ5.Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs.
• Synonyms: C22orf12; DGCRK6; Gy1