DISC1 Rabbit Monoclonal Antibody [Clone ID: R03-7F5]

CAT#: TA384106

DISC1 Rabbit monoclonal Antibody

Product Images

Western blot detection of DISC1 in K562,Rat Brain,C6,3T3,Hela cell lysates using DISC1 Rabbit mAb(1:1000 diluted).Predicted band size:94kDa.Observed band size:94kDa.

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  Immunocytochemistry of DISC1(green) in Hela cells using DISC1 Rabbit mAb at dilution 1/50, and DAPI(blue)

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  Immunohistochemistry of DISC1 in paraffin-embedded Human colon cancer tissue using DISC1 Rabbit mAb at dilution 1/2

Specifications

Product Data

• Clone Name: R03-7F5
• Applications: IF, IHC, IP, WB
• Recommended Dilution: WB: 1/1000
  IHC: 1/20-1/100
  ICC/IF: 1/2000
  IP: 1/20
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Recombinant protein of human DISC1
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 94 kDa; Observed MW: 94 kDa
• Gene Name: disrupted in schizophrenia 1
• Database Link:
  Entrez Gene 27185 Human
  UniProt ID Q9NRI5
• Background: Swiss-Prot Acc.Q9NRI5.Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation.
• Synonyms: C1orf136; FLJ13381; FLJ21640; FLJ25311; FLJ41105; KIAA0457; SCZD9