EIF4EBP1 Rabbit Polyclonal Antibody

CAT#: TA384161

4E BP1 Rabbit polyclonal Antibody

Product Images

Immunohistochemical analysis of paraffin-embedded human breast carcinoma, using eIF4EBP1 Antibody.

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  Immunofluorescent analysis of HeLa cells, using eIF4EBP1 Antibody.

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  Western blot analysis of eIF4EBP1 expression in K562 cell lysate.

Specifications

Product Data

• Applications: FC, IF, IHC, IP, WB
• Recommended Dilution: WB: 1/1000-1/2000
  IHC: 1/50-1/200
  ICC/IF: 1/50-1/200
  IP: 1/50
  FC: 1/50
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthesized peptide derived from human eIF4EBP1
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: lot specific
• Purification: Affinity Chromatography
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: 18kDa
• Gene Name: eukaryotic translation initiation factor 4E binding protein 1
• Database Link:
  Entrez Gene 1978 Human
  UniProt ID Q13541
• Background: Swiss-Prot Acc.Q13541.Translation repressor protein 4E-BP1 (also known as PHAS-1) inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. Hyperphosphorylation of 4E-BP1 disrupts this interaction and results in activation of cap-dependent translation. Both the PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E-BP1 activity.
• Synonyms: 4E-BP1; 4EBP1; BP-1; MGC4316; PHAS-I