IRE1 (ERN1) Rabbit Polyclonal Antibody

CAT#: TA384187

Phospho-IRE1 (Ser724) Rabbit polyclonal Antibody

Product Images

Western blot analysis of Phospho-IRE1 (S724) expression in (1) K562 cell lysate treated with AP; (2) Untreated K562 cell lysate.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1/500-1/2000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthesized peptide derived from human Phospho-IRE1 (S724) (Phosphorylated)
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: lot specific
• Purification: Affinity Chromatography
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: 110kDa
• Gene Name: endoplasmic reticulum to nucleus signaling 1
• Database Link:
  Entrez Gene 2081 Human
  UniProt ID O75460
• Background: Swiss-Prot Acc.O75460.Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.
• Synonyms: FLJ30999; hIRE1p; IRE1; Ire1-alpha; IRE1a; IRE1P; MGC163277; MGC163279