Fibrillarin (FBL) Rabbit Polyclonal Antibody

CAT#: TA384211

Fibrillarin Rabbit polyclonal Antibody

Product Images

Immunohistochemical analysis of paraffin-embedded human testis, using Fibrillarin Antibody.

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  Immunofluorescent analysis of Hela cells, using Fibrillarin Antibody .

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  Western blot analysis of Fibrillarin expression in HepG2 cell lysate.

Specifications

Product Data

• Applications: FC, IF, IHC, IP, WB
• Recommended Dilution: WB: 1/500-1/2000
  IHC: 1/50-1/100
  ICC/IF: 1/50-1/100
  FC: 1/50
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthesized peptide derived from human Fibrillarin
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: lot specific
• Purification: Affinity Chromatography
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: 33kDa
• Gene Name: fibrillarin
• Database Link:
  Entrez Gene 2091 Human
  UniProt ID P22087
• Background: Swiss-Prot Acc.P22087.Fibrillarin is a 2'-O-methyltransferase located in fibrillar regions and Cajal bodies of the nucleolus, where RNA transcription and pre-RNA processing take place. Fibrillarin associates with several other structual proteins as well as box C/D snoRNA to form a complex that functions in pre-rRNA processing, pre-rRNA methylation and ribosome assembly. This complex catalyzes site-specific 2'-O-ribose methylation of targeted nucleotides within the rRNA sequence. The sequence, structure and function of fibrillarin are highly conserved and fibrillarin gene expression is essential for early embryonic development.
• Synonyms: FIB; FIB1; fibrillarin; FLRN; RNU3IP1