FGFR4 Mouse Monoclonal Antibody [Clone ID: 7H1]

CAT#: TA384227

FGFR4 Mouse monoclonal Antibody

Product Images

Western blot analysis using FGFR4 mouse mAb against extracellular domain of human FGFR4 (aa22-369).

• 

  Confocal immunofluorescence analysis of methanol-fixed HEK293 cells trasfected with FGFR4-hIgGFc using FGFR4 mouse mAb(green), showing membrane localization. Blue: DRAQ5 fluorescent DNA dye.

Specifications

Product Data

• Clone Name: 7H1
• Applications: IF
• Recommended Dilution: ICC: 1/200-1/1000
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified recombinant extracellular fragment of human FGFR4 fused with hIgGFc tag expressed in HEK293 cell line.
• Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.03% Proclin 300, pH 7.3.
• Concentration: lot specific
• Purification: Ascitic Fluid
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: 87.9kDa
• Gene Name: fibroblast growth factor receptor 4
• Database Link:
  Entrez Gene 2264 Human
  UniProt ID P22455
• Background: Swiss-Prot Acc.P22455.FGFR4: fibroblast growth factor receptor 4. Entrez Protein NP_002002. It is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms,as indicated for members 1-3. This particular family member preferentially binds acidic fibroblastgrowth factor and, although its specific function is unknown, it is overexpressed in gynecologicaltumor samples, suggesting a role in breast and ovarian tumorigenesis.
• Synonyms: CD334; FGFR-4; JTK2; MGC20292; OTTHUMP00000161430; TKF