GDF15 Rabbit Monoclonal Antibody [Clone ID: R04-8I1]

CAT#: TA384293

GDF15 Rabbit monoclonal Antibody

Product Images

Western blot detection of GDF15 in Hela cell lysates using GDF15 Rabbit mAb(1:1000 diluted).Predicted band size:34kDa.Observed band size:34kDa.

Specifications

Product Data

• Clone Name: R04-8I1
• Applications: WB
• Recommended Dilution: WB: 1/1000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide of human GDF15
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 34 kDa; Observed MW: 34 kDa
• Gene Name: growth differentiation factor 15
• Database Link:
  Entrez Gene 9518 Human
  UniProt ID Q99988
• Background: Swiss-Prot Acc.Q99988.Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:23468844, PubMed:29046435). Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which contitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions (PubMed:28953886). On hepatocytes, inhibits growth hormone signaling .
• Synonyms: GDF-15; MIC-1; MIC1; NAG-1; NRG-1; PDF; PLAB; PTGF-beta; PTGFB