HLTF Rabbit Monoclonal Antibody [Clone ID: R03-1E4]

CAT#: TA384437

HLTF Rabbit monoclonal Antibody

Product Images

Western blot detection of HLTF in Hela cell lysates using HLTF Rabbit mAb(1:1000 diluted).Predicted band size:114kDa.Observed band size:114kDa.

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  Immunocytochemistry of HLTF(green) in Hela cells using HLTF Rabbit mAb at dilution 1/50, and DAPI(blue)

Specifications

Product Data

• Clone Name: R03-1E4
• Applications: IF, WB
• Recommended Dilution: WB: 1/2000-1/10000
  ICC/IF: 1/20
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide of human HLTF
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 114 kDa; Observed MW: 114 kDa
• Gene Name: helicase-like transcription factor
• Database Link:
  Entrez Gene 6596 Human
  UniProt ID Q14527
• Background: Swiss-Prot Acc.Q14527.Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters . These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.
• Synonyms: HIP116; HIP116A; HLTF1; RNF80; SMARCA3; SNF2L3; ZBU1