IDE Rabbit Polyclonal Antibody

CAT#: TA384478

Insulin Degrading Enzyme Rabbit polyclonal Antibody

Product Images

Western blot analysis of IDE expression in HepG2 cell lysate.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1/500-1/2000
  IHC: 1/50-1/100
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthesized peptide derived from human IDE
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: lot specific
• Purification: Affinity Chromatography
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: 118kDa
• Gene Name: insulin degrading enzyme
• Database Link:
  Entrez Gene 3416 Human
  UniProt ID P14735
• Background: Swiss-Prot Acc.P14735.This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid.
• Synonyms: FLJ35968; Insulinase; INSULYSIN