IRF1 Rabbit Polyclonal Antibody

CAT#: TA384543

IRF1 Rabbit polyclonal Antibody

Product Images

Immunohistochemical analysis of paraffin-embedded rat kidney, using IRF1 Antibody.

• 

  Immunofluorescent analysis of Hela cells, using IRF1 Antibody .

• 

  Western blot analysis of IRF1 expression in Jurkat cell lysate.

Specifications

Product Data

• Applications: FC, IF, IHC, IP, WB
• Recommended Dilution: WB: 1/500-1/1000
  IHC: 1/50-1/100
  ICC/IF: 1/50-1/100
  IP: 1/50
  FC: 1/50
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthesized peptide derived from human IRF1
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: lot specific
• Purification: Affinity Chromatography
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: 48kDa
• Gene Name: interferon regulatory factor 1
• Database Link:
  Entrez Gene 3659 Human
  UniProt ID P10914
• Background: Swiss-Prot Acc.P10914.Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and activates those genes. Acts as a tumor suppressor. Defects in IRF1 are a cause of gastric cancer (GASC) [MIM:613659]; also called gastric cancer inTinal or stomach cancer. Gastric cancer is a malignant disease which starts in the stomach, can spread to the esophagus or the small inTine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body.
• Synonyms: IRF-1; MAR; OTTHUMP00000198266