Integrin alpha 5 (ITGA5) Rabbit Polyclonal Antibody

CAT#: TA384556

Integrin alpha 5 Rabbit polyclonal Antibody

Product Images

Western blot analysis of Integrin alpha 5 expression in Mouse heart lysate.

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  Immunofluorescent analysis of MCF-7 cells, using Integrin alpha 5 Antibody.

Specifications

Product Data

• Applications: FC, IF, IHC, IP, WB
• Recommended Dilution: WB: 1/1000-1/2000
  IHC: 1/50-1/200
  ICC/IF: 1/50-1/200
  IP: 1/50
  FC: 1/50
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthesized peptide derived from human Integrin alpha 5
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: lot specific
• Purification: Affinity Chromatography
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: 150kDa
• Gene Name: integrin subunit alpha 5
• Database Link:
  Entrez Gene 3678 Human
  UniProt ID P08648
• Background: Swiss-Prot Acc.P08648.Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1.
• Synonyms: CD49e; FNRA; VLA-5; VLA5A