JARID2 Rabbit Monoclonal Antibody [Clone ID: R06-1K4]

CAT#: TA384578

Protein Jumonji Rabbit monoclonal Antibody

Product Images

Western blot detection of Jarid2 in K562,C6 cell lysates using Jarid2 Rabbit mAb(1:1000 diluted).Predicted band size:139kDa.Observed band size:139kDa.

Specifications

Product Data

• Clone Name: R06-1K4
• Applications: WB
• Recommended Dilution: WB: 1/1000
• Reactivities: Human, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide of human Jarid2
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 139 kDa; Observed MW: 139 kDa
• Gene Name: jumonji and AT-rich interaction domain containing 2
• Database Link:
  Entrez Gene 3720 Human
  UniProt ID Q92833
• Background: Swiss-Prot Acc.Q92833.Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.
• Synonyms: JMJ