KIF7 Mouse Monoclonal Antibody [Clone ID: 2A7-10B8-9A9]

CAT#: TA384607

KIF7 (2A7) Mouse monoclonal Antibody

Product Images

Immunofluorescence analysis of Mouse-colon tissue. 1,Kif 7 Monoclonal Antibody(3F8)(red) was diluted at 1:200(4°C,overnight). 2, Cy3 labled Secondary antibody was diluted at 1:300(room temperature, 50min).3, Picture B: DAPI(blue) 10min. Picture A:Target. Picture B: DAPI. Picture C: merge of A+B

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  IHC staining of Mouse Kidney tissue, diluted at 1:200.

Specifications

Product Data

• Clone Name: 2A7-10B8-9A9
• Applications: IF, IHC
• Recommended Dilution: IHC: 1/200
  IF: 1/50-200
• Reactivities: Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Synthetic Peptide of Kif 7
• Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.03% Proclin 300, pH 7.3.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Gene Name: kinesin family member 7
• Database Link:
  Entrez Gene 374654 Human
  UniProt ID Q2M1P5
• Background: Swiss-Prot Acc.Q2M1P5.Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms (PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes . Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation . Involved in the regulation of epidermal differentiation and chondrocyte development .
• Synonyms: EQYK340; MGC120653; MGC138476; MGC138478; UNQ340