LRRK2 Rabbit Polyclonal Antibody

CAT#: TA384679

Phospho-LRRK2 (Ser395) Rabbit polyclonal Antibody

Product Images

Western blot analysis of Filamin A Phosphorylation in WTLRRK2 lysates treated LRRK2 using Phospho-LRRK2 (Ser395) antibody.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1/500-1/1000
  ICC/IF: 1/50-1/200
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthesized peptide derived from human Phospho-LRRK2 (S935) (Phosphorylated)
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: lot specific
• Purification: Affinity Chromatography
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: 286kDa
• Database Link:
  UniProt ID Q5S007
• Background: Swiss-Prot Acc.Q5S007.The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Plays a role in synaptic vesicle trafficking. Phosphorylates PRDX3. Has GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease.