NUMB Rabbit Monoclonal Antibody [Clone ID: R09-2I5]

CAT#: TA384905

NUMB Rabbit monoclonal Antibody

Product Images

Western blot detection of NUMB in 3T3,C6,Rat Brain,MCF7 cell lysates using NUMB Rabbit mAb(1:1000 diluted).Predicted band size:71kDa.Observed band size:71kDa.

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  Immunohistochemistry of NUMB in paraffin-embedded Human lung cancer tissue using NUMB Rabbit mAb at dilution 1/50

Specifications

Product Data

• Clone Name: R09-2I5
• Applications: IHC, IP, WB
• Recommended Dilution: WB: 1/1000
  IHC: 1/200
  IP: 1/20
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Recombinant protein of human NUMB
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 71 kDa; Observed MW: 71 kDa
• Gene Name: NUMB, endocytic adaptor protein
• Database Link:
  Entrez Gene 8650 Human
  UniProt ID P49757
• Background: Swiss-Prot Acc.P49757.Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.
• Synonyms: h-Numb; S171