Phospholipase A2 IIA (PLA2G2A) Rabbit Monoclonal Antibody [Clone ID: R09-4F9]
Other products for "PLA2G2A"
Specifications
Product Data | |
Clone Name | R09-4F9 |
Applications | WB |
Recommended Dilution | WB: 1/1000 |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Isotype | IgG |
Clonality | Monoclonal |
Immunogen | A synthetic peptide of human Secretory phospholipase A2 |
Formulation | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
Concentration | lot specific |
Purification | Affinity Purified |
Conjugation | Unconjugated |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Stability | 1 year |
Predicted Protein Size | Calculated MW: 16 kDa; Observed MW: 16 kDa |
Gene Name | phospholipase A2 group IIA |
Database Link | |
Background | Swiss-Prot Acc.P14555.Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (PubMed:2925633). Thought to participate in the regulation of phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Independent of its catalytic activity, acts as a ligand for integrins (PubMed:18635536, PubMed:25398877). Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 (PubMed:18635536, PubMed:25398877). Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:25398877). Induces cell proliferation in an integrin-dependent manner (PubMed:18635536). |
Synonyms | MOM1; NPS-PLA2; PLA2; PLA2B; PLA2L; PLA2S; PLAS1; RASF-A; sPLA2 |
Reference Data |
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